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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Chrysin, Paclitaxel
Phytochemical Name Chrysin (PubChem CID: 5281607 )
Anticancer drug Name Paclitaxel (PubChem CID: 36314 )
Structure of
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2D MOL 3D MOL
Structure of
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Paclitaxel
Adverse Reactions Bronchospasmodic dyspnoea, hypotension, peripheral neuropathy and bone, joint and muscle aches and pains. This was inferred cold nature anticancer drug.
Recommendations Hot: Dimocarpus longan; Terminalia chebula; Astragalus membranaceus; Lycopodium japonicum
Reference Malignant tumors in the era of immunotherapy based on traditional Chinese medicine's "cold and hot theory" Construction of integrated traditional Chinese and Western medicine treatment paradigm[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine,2023,32(12):1712-1716. DOI:10.3969/j.issn.1008-8849.2023.12.022.　　ref_link
Combination Pair ID: 997
Ref_1
Pair Name Chrysin, Paclitaxel
Disease Info [ICD-11: 2A00-2F9Z] Solid tumour or cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression CASP3 hsa836
Up-regulation Expression BAX hsa581
Up-regulation Expression HAVCR1 hsa26762
Up-regulation Expression NFKB1 hsa4790
Up-regulation Expression COX2 hsa4513
Down-regulation Expression BCL2 hsa596
Down-regulation Expression SOD1 hsa6647
Down-regulation Expression CAT hsa847
Down-regulation Expression GPX3 hsa2878
Down-regulation Expression GSTK1 hsa373156
In Vivo Model Thirty-five male Sprague-Dawley rats were divided into five groups (n = 7): Group I (normal control), Group II (CR alone at a dose of 50 mg/kg), Group III (Pax at a dose of 2 mg/kg), Group IV (Pax+CR 25), and Group V (Pax+CR 50).
Result CR exhibited the ability to reduce oxidative DNA damage, exert anti-apoptotic and anti-inflammatory properties, and mitigate the toxic effects of Pax-induced hepatorenal toxicity.
03. Reference
No. Title Href
1 Chrysin attenuates paclitaxel-induced hepatorenal toxicity in rats by suppressing oxidative damage, inflammation, and apoptosis. Life Sci. 2023 Nov 1;332:122096. doi: 10.1016/j.lfs.2023.122096. Click
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